Plaque psoriasis is a chronic autoimmune skin condition that affects over 7 million Americans. It causes red, scaly patches that can crack, bleed, and severely impact daily life.
While genetics and immune dysfunction play a major role, what many people don’t realize is that certain medications are now known to trigger or worsen psoriasis symptoms — even if the drug was prescribed for something totally unrelated.
⚠️ Medications That Can Trigger or Worsen Plaque Psoriasis
💊 Beta-Blockers
Used for high blood pressure, anxiety, and heart issues.
Examples: atenolol, propranolol, metoprolol
▶️ Known to trigger psoriasis flares or cause new onset in genetically susceptible individuals.
💊 Lithium
Used to treat bipolar disorder and depression.
▶️ One of the strongest drug triggers for chronic plaque psoriasis.
▶️ May lead to thick, treatment-resistant plaques.
💊 Antimalarials
Used for malaria, lupus, and rheumatoid arthritis.
Examples: hydroxychloroquine, chloroquine
▶️ Often causes flare-ups within weeks of starting treatment.
💊 Interferons
Used for hepatitis and multiple sclerosis.
▶️ May overstimulate the immune system and trigger psoriatic inflammation.
💊 NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
Used for pain and inflammation.
Examples: ibuprofen, naproxen
▶️ In some people, NSAIDs worsen skin inflammation or interfere with psoriasis treatments.
💊 ACE Inhibitors
Used for blood pressure and heart conditions.
Examples: lisinopril, enalapril
▶️ Linked to new-onset or worsening psoriasis in some patients.
💊 Tetracycline Antibiotics
Used for acne and infections.
▶️ May contribute to photosensitive psoriasis reactions when combined with sun exposure.
🔍 Noticing a Flare? What You Should Do
If your psoriasis worsened after starting one of these medications:
✔️ Do not stop the medication suddenly — consult your doctor.
✔️ Take photos of your flare-ups and track timing relative to new prescriptions.
✔️ Ask about alternatives with lower skin risks.
✔️ Consider referral to a dermatologist for combined care.
✔️ Explore anti-inflammatory diets or stress-reduction techniques that support skin health.